NTU Bio-Tech

Li-Ying, Sung
Job Title Professor
Name Li-Ying, Sung
Office Tel No. 886-2-3366-6015~16
Email liyingsung@ntu.edu.tw
Research expertise Animal Cloning, Nuclear Reprogramming, Embryo Biology, Embryonic Stem Cell Biology
Year Paper Title
2021 22(1):460, (SCI)
2021 22(2):661, (SCI)
2020 21(3):794, (SCI)
2020 133(9):jcs240200, (SCI)
2019 Chang WF, Wu YH, Xu J, Sung LY*. , Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer., International Journal of Molecular Sciences, 20(5), (SCI)
2018 Chang CC, Keppeke GD, Sung LY*, Liu JL*, Inter-filament interaction between IMPDH and CTPS cytoophidia, FEBS Journal, 285, 20, pp3753-3768, (SCI)
2018 Lin WC, Chakraborty A, Huang SC, Wang PY, Hsieh YJ, Chien KY, Lee YH, Chang CC, Tang HY, Lin YT, Tung CS, Luo JD, Chen TW, Lin TY, Cheng ML, Chen YT, Yeh CT, Liu JL, Sung LY, Shiao MS, Yu JS, Chang YS, Pai LM*., Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase., Cell Reports, 24, 10, pp2733-2745, (SCI)
2018 Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY*, Liu JL*, IMP/GTP balance modulates cytoophidium assembly and IMPDH activity, Cell Div, 13:5, (SCI)
2017 Chang CC, Jeng YM, Peng M, Keppeke GD, Sung LY*, Liu JL*, CTP synthase forms the cytoophidium in human hepatocellular carcinoma, Experimental, S0014-4827(17)30576-1, (SCI)
2017 Wu FJ, Lin TY, Sung LY, Chang WF, Wu PC, Luo CW. , BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia, Sci Signal.(Cover story), 10(477). , eaal1910, (SCI)
2016 Chang WF, Hwu YM, Xu J, Lin CJ, Wang SW, Cheng AS, Lu J, Lu CH, Sung LY*., Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells, PLoS ONE , 1, 11, ppe0165715-, (SCI)
2016 Chang CC, Chang WF, Xu J, Cheng AS, Chang CC, Nagy ZP, Yang CC, Ding ST, Sung LY*, Production of Live Offspring from Vitrified-Warmed Oocytes Collected at Metaphase I Stage, PLoS ONE, 11, 6, ppe0157785-, (SCI)
2016 Liu CC, Chang TC, Lin YT, Yu YL, Ko BS, Sung LY*, Liou JY*. , Paracrine Regulation of Matrix Metalloproteinases Contributes to Cancer Cell Invasion by Hepatocellular Carcinoma Secreted 14-3-3σ, Oncotarget, doi: 10.18632/oncotarget.9234, (SCI)
2015 Chang CC, Lin WC, Pai LM, Lee HS, Wu SC, Ding ST, Liu JL*, Sung LY*. (*Corresponding authors), Cytoophidium assembly reflects upregulation of IMPDH activity., pii: jcs.175265. [Epub ahead of print], (SCI)
2015 Cheng YT, Yeih DF, Liang SM, Chien CY, Yu YL, Ko BS, Jan YJ, Kuo CC, Sung LY, Shyue SK, Chen MF, Yet SF, Wu KK, Liou JY., Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells., Int J Cardiol, 201, pp441-448, (SCI)
2015 Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourc'his D, Bestor T, Sung LY, Lin SP., Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency., Reproduction, 150(4), pp245-256, (SCI)
2014 Sung LY, Chang WF, Zhang Q, Liu CC, Liou JY, Chang CC, Ou-Yang H, Guo R, Fu H, Cheng WT, Ding ST, Chen CM, Okuka M, Keefe DL, Chen YE, Liu L*, Xu J*., Telomere elongation and naïve pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer, Cell Reports, 9, 5, pp1603-1609, (SCI)
2014 Aughey GN*, Grice SJ*, Shen QJ*, Xu Y, Chang CC, Azzam G, Wang PY, Freeman-Mills M, Pai LM, Sung LY, Yan J and Liu JL. , Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism, pii: BIO201410165, [Epub ahead of print], (SCI)
2014 Liu CC, Jan YJ, Ko BS, Wu YM, Liang SM, Chen SC, Lee YM, Liu TA, Chang TC, Wang J, Shyue SK, Sung LY*, Liou JY*. (*Corresponding authors)., 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma, 14, 1, pp425-436, (SCI)
2014 Gou KM*, Chang CC*, Shen QJ, Sung LY** and Liu JL**. (*These authors contributed equally to this work; **Corresponding authors)., CTP synthase forms cytoophidia in the cytoplasm and nucleus. , Experimental Cell Research , 323, (1), pp242-253, (SCI)
2014 Chang WF, Xu J, Chang CC, Yang SH, Li HY, Hsieh-Li HM, Tsai MH, Wu SC, Cheng WTK, Liu JL* and Sung LY*. (*Corresponding authors)., SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice. (*Corresponding authors)., Brain Structure & Function, [Epub ahead of print], (SCI)
2013 Chen, F. Du, J. Xu, W.F. Chang, C.C. Liu, H.Y. Su, T.A. Lin, J.C. Ju, W.T.K. Cheng, S.C. Wu, Y.E. Chen, L.Y. Sung* (*通訊作者) , Synergistic Effect of Trichostatin A and Scriptaid on the Development of Cloned Rabbit Embryos. , Theriogenology, 79, pp1284-1293, (SCI)
2012 Li Y, Pal R, Sung LY, Feng H, Miao W, Cheng SY, Tian C, Cheng T. An Opposite Effect of the CDK Inhibitor, p18(INK4c) on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells. PLoS ONE.
2012 Chang TC, Liu CC, Hsing EW, Liang SM, Chi YH, Sung LY, Lin SP, Shen TL, Ko BS, Yen BL, Yet SF, Wu KK, Liou JY. 14-3-3s Regulates b-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3b. PLoS ONE. 2012;7(6):e40193. (SCI)
2012 Chen CH, Xu J, Chang WF, Liu CC, Su HY, Eugene Chen Y, Du F, Sung LY*. Dynamic profiles of Oct-4, Cdx-2 and acetylated H4K5 in in-vivo-derived rabbit embryos. Reproductive BioMedicine Online. 2012 Oct;25(4):358-70. (SCI, *Corresponding Author)
2012 Chen CH., Chang WF., Liu CC., Su HY., Shyue SK., Cheng W. TK., Y. Chen E., Wu SC., Du F., Sung LY.*, Jie Xu*. Spatial and Temporal Distribution of Oct-4 Expression and H4K5 Acetylation in Rabbit Embryos. Reproductive BioMedicine Online. 2012 Apr;24(4):433-42. (SCI, *Corresponding Author)
2011 Sung LY, Chen CH, Xu J, Lin TA, Su HY, Chang WF, Liu CC, Sung YS, Cheng WTK, Zhang J, X. C. Tian, Ju JC, Chen TE, Wu SC, Du F. Follicular oocytes better support development in rabbit cloning than oviductal oocytes. Cellular Reprogramming. 2011 Dec;13(6):503-12. Epub 2011 Oct 26. (SCI)
2010 Chang CC, Lin CJ, Sung LY, Kort HI, Tian XC, Nagy ZP. Impact of phase transition on the mouse oocyte spindle during vitrification. Reprod Biomed Online. 2010 Oct 31. [Epub ahead of print] (SCI)
2010 Sung LY., Chang CC, Amano T, Lin CJ, Amano M, Treaster SB, Xu J, Chang WF, Nagy ZP, Yang X, Tian XC. Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes. Cellular Reprogramming. 2010 Apr;12(2):203-11. (SCI)
2010 Chang CC, Gao S, Sung LY, Corry GN, Ma Y, Nagy ZP, Tian XC, Rasmussen TP. Rapid elimination of the histone variant MacroH2A from somatic cell heterochromatin after nuclear transfer. Cell Reprogram. 2010 Feb;12(1):43-53. (SCI)
2010 Lin TA, Chen CH, Sung LY, Carter MG, Chen YE, Du F, Ju JC, Xu J. Open-pulled straw vitrification differentiates cryotolerance of in vitro cultured rabbit embryos at the eight-cell stage. Theriogenology. 2010 Dec 6. [Epub ahead of print]. (SCI)
2010 Chang CC, Sung LY, Lin CJ, Kort HI, Yang X, Tian XC, Nagy ZP. The oocyte spindle is preserved by 1,2-propanediol during slow freezing. Fertil Steril. 2010 Mar 15;93(5):1430-9. (SCI)
2009 Chang CC., Sung LY., Amano T., Tian XC., Yang X., Nagy ZP. Nuclear transfer and oocyte cryopreservation. Reproduction, Fertility and Development, 2009;21(1):37-44. (SCI)
2009 Suteevun-Phermthai T, Curchoe CL, Evans AC, Boland E, Rizos D, Fair T, Duffy P, Sung LY, Du F, Chaubal S, Xu J, Wechayant T, Yang X, Lonergan P, Parnpai R, Tian XC. Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves. Anim Reprod Sci. 2009 Nov;116(1-2):19-27. (SCI)
2009 Amano, T., Papanikolaou, T., Sung, L-Y., Conover, J., and Yang, X. Nuclear Transfer Embryonic Stem Cells Provide an In Vitro Culture Model for Parkinson's Disease. Cloning Stem Cells. 2009 Mar;11(1):77-88. (SCI)
2009 Du F., Xu J., Zhang J., Gao S., Carter MG., He C., Sung LY., Chaubal S., Fissore R. A., Tian XC., Yang X. and Chen YE. Beneficial Effect of Young Oocytes for Rabbit Somatic Cell Nuclear Transfer. Cloning and Stem Cells. 2009 Mar;11(1):131-40. (SCI)
2009 Smith, S.L., Everts, R.E., Sung, L-Y., Du, F., Page, R.L., Henderson, B., Rodriguez-Zas, S.L., Nedambale, T.L., Renard, J.P., Lewin, H.A., Yang, X., Tian, X.C. Gene Expression Profiling of Single Bovine Embryos Uncovers Significant Effects of In Vitro Maturation, Fertilization and Culture. Mol. Reprod. Dev., 2009 Jan;76(1):38-47. (SCI)
2007 Tian, X.C., Smith, S.L., Zhang, S.Q., Kubota, C., Curchoe, C., Xue, F., Yang, L., Du, F., Sung, L-Y., Yang, X. Nuclear reprogramming by somatic cell nuclear transfer – the cattle story. Soc Reprod Fertil Suppl. 2007;64:327-39. Review.
2007 Lonergan P, Evans AC, Boland E, Rizos D, Fair T, Duffy P, Sung LY, Du F, Chaubal S, Xu J, Yang X, Tian XC. Pregnancy and fetal characteristics after transfer of vitrified in vivo and cloned bovine embryos. Theriogenology. 2007 Nov;68(8):1128-37. (SCI)
2007 Sung, L-Y., Shen, P-C., Jeong, BS., Xu, J., Chang, C-C., Cheng, WTK., Wu, J-S., Lee, S-N., Broek, D., Faber, D., Tian, XC., Yang, X., Du, F. Premature Chromosome Condensation Is Not Essential for Nuclear Reprogramming in Bovine Somatic Cell Nuclear Transfer. Biol Reprod., 2007 Feb; 76(2):232-40. (SCI)
2007 Yang, X., Cheng, T., Sung, L-Y,. Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Tuck, D.P., Inoue, K., Weissman, S.M. Reply to "On the cloning of animals from terminally differentiated cells". Nature Genetics, 2007 Feb; 39(2):137-8. (SCI)
2006 Sung, L-Y. Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Chang, C-C., Inoue, K., Kuo, K., Lian, J., Li, A., Tian, X.C., Tuck, D.P., Weissman, S.M., Cheng, T., Yang, X. Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nature Genetics, 2006 Nov; 38(11): 1323-8. (SCI)
2006 Du, F., Shen, P.C., Xu, J., Sung, L-Y., Jeong, BS., Nedambale, L.T., Riesen, J., Tian, C.X., Cheng, W.T.K., Lee, S.N., Yang, X. The cell agglutination agent, phytohemagglutinin-L, improves the efficiency of somatic nuclear transfer cloning in cattle (Bos taurus). Theriogenology, 2006, 65(3): 642-57. (SCI)
2005 Enright, B.P., Sung, L-Y., Chang, C.C., Yang, X., Tian, X.C. Methylation and Acetylation Characteristics of Cloned Bovine Embryos from Donor Cells Treated with 5-aza-2'-deoxycytidine. Biol Reprod., 2005, 72: 944-948. (SCI)
2005 Smith, S.L., Everts, R.E., Tian, X.C., Du, F., Sung, L-Y., Rodriguez-Zas, S.L., Jeong, B.S., Renard, J.P., Lewin, H.A., Yang, X. Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. Proc Natl Acad Sci U S A. 2005, 102(49): 17582-7. (SCI)
2005 Wang, L., Duan, E., Sung, L-Y., Jeong, B-S., Yang, X., and Tian, CT. Generation and Characterization of Pluripotent Stem Cells from Cloned Bovine Embryos. Biol Reprod., 2005, 73: 149 – 155. (SCI)
2004 Sung, L-Y., Du, F., Xu, J., Chang, W., Jiang, S., Tian, X.C. and Yang, X. The effect of albumin and sodium citrate on the development of in vitro produced bovine embryos under different oxygen tension. Reprod Nutri Dev., 2004, 44:551-564. (SCI)
2004 Liu, J-L., Sung, L-Y., Du, F., Julian, M., Jiang, S., Barber, M., Xu, J., Tian, X. C. and Yang, X. Differential development of rabbit embryos derived from parthenogenesis and nuclear transfer. Mol. Reprod. Dev., 2004, 68:58-64. (SCI)
2002 Liu, J-L., Sung, L-Y., Barber, M., and Yang, X. Hypertonic Medium Treatment for Localization of Nuclear Material in Bovine Metaphase II Oocytes. Biol Reprod., 2002, 66: 1342 - 1349. (SCI)
2002 Du, F., Sung, L-Y., Tian, X. C. and Yang, X. Differential cytoplast requirement for embryonic and somatic cell nuclear transfer in cattle. Mol. Reprod. Dev., 2002, 63:183-191. (SCI)
2002 Liu, J-L., Sung, L-Y., Tian, X. C. and Yang, X. Hypertonicity-Induced Projections Reflect Cell Polarity in Mouse Metaphase II Oocytes: Involvement of Microtubules, Microfilaments, and Chromosomes. Biol Reprod., 2002, 67: 1853 - 1863. (SCI)