NTU Bio-Tech

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Introduction

This institute has been established in August 2006 and began to enroll PhD students since that academic year. The mission of this institute is to provide great research and teaching environment for the following fields that match the directions of our national policies: bioinformatics, nano-biomedical research, tissue engineering and regenerative medicine, genomics and proteomics. 

Implication of Logo

DNA is at the center of life. Many studies on life science or development in biotechnology depend largely on unraveling it. Genomic approach thus forms the intersection core among the 3 fields of plant, animal, and microbial biotech in this institute. The microbe in the leaf indicates plant-microbe interactions. The woman head represents the animal and medical fields. The boxes are symbolic for microarray results and represent the bioinformatics. These symbols linked together indicate cross-disciplinary researches that are flourishingly developing in this institute.

Interview of New Assistant Professor, Dr. Shu-Han, Yu

Today we interviewed our new faculty, Dr. Shu-Han Yu, who has immuno-oncology, immune modulation, tumor microenvironment, and microbiome professional with 9+ years of academic research experience and 4+ years of industrial experience. She has committed to transforming expertise in translational medicine into non-small-cell lung cancer precision medicine, microbiome profiling, biomarker discovery, characterization, clinical validation, and potential diagnostics.

Interview of New Director, Professor Mong-Hsun Tsai

Today we are very happy to interview the new director of Institute of Biotechnology (IOB), Prof. Mong-Hsun Tsai, to talk about his research journey. Graduated from the Department of Zoology at National Taiwan University (NTU), Prof. Tsai has established solid biology backgrounds. Prof. Tsai then decided to proceed his master at National Tsing Hua University (NTHU). His study mainly focused on radiation and heavy metal (such as arsenic) induced damages in molecular, cellular, and phenotype levels. For Dr. Tsai’s dissertation at National Yang Ming University, he mainly studied health effects of chronic low-dose radiation exposed subjects who lived in Co60-contaminated buildings for more than 10 years in Taiwan. Dr. Tsai stayed in NIH for 4 years and came back to NTU as an assistant professor in 1996. Prof. Tsai has been employing biochips and bioinformatics tools for agriculture applications and to discover specific biomarkers for cancer outcome prediction. 

Interview of Professor Jen-Chih Chen

Our interviewee today is Prof Jen-Chih Chen, driving by his curiosity, he is now an associate professor in the Institute of Biotechnology (IOB), and his research expertise includes plant defense, molecular biology, as well as bioenergy.

From the interview, we can feel that Dr. Chen is full of curiosity. He is interested in all sorts of biological phenomena, and enjoys dissecting them. He may have changed his research focus to animal studies, but through searching and experiencing, he returned to his beloved plant science. He told us to keep on trying new things and new ways, and by doing so, we may be able to find something really surprising. Of course, there are always challenges, and keeping on trying and enriching your knowledge should carry you a long way during your research.

Interview of Professor Chi-Te Liu

Today we invite Dr. Chi-Te Liu, an associate professor of the Institute of Biotechnology (IOB), to share his journey of research and development. Dr. Liu’s research interests focus on S.E.A, i.e. Symbiosis (Microbe-Plant interactions), Environmental microbiology, and Agricultural biotechnology. The current projects in his lab including (1) development of multifunctional PGPR agents (biofertilizers & biopesticides), (2) exploring the molecular mechanisms of plant-microbe interactions, (3) biodegradation of synthetic plastics, and (4) employing soil-based microbial batteries for sustainable agriculture and energy.Today we invite Dr. Chi-Te Liu, an associate professor of the Institute of Biotechnology (IOB), to share his journey of research and development. Dr. Liu’s research interests focus on S.E.A, i.e. Symbiosis (Microbe-Plant interactions), Environmental microbiology, and Agricultural biotechnology. The current projects in his lab including (1) development of multifunctional PGPR agents (biofertilizers & biopesticides), (2) exploring the molecular mechanisms of plant-microbe interactions, (3) biodegradation of synthetic plastics, and (4) employing soil-based microbial batteries for sustainable agriculture and energy.

Interview of Professor Je-Ruei Liu

Today we invite Dr. Je-Ruei Liu, professor of the Institute of Biotechnology (IOB) and vice dean of College of Bio-Resources and Agriculture, to share his journey of research. With the fast-pace of modern lifestyle, dietary habits are characterized by erratic eating patterns . Malnutrition, unhealthy diet, smoking, stress and so on, are the presentations of unhealthy life lifestyle. Unwanted diseases and afflictions arise from such dietary habits. Obesity is on the rise and has become a chronic problem, along with aging, diabetes, as well as high blood pressure. Another issue in the modern lifestyle is the declining birth rate. More and more people choose to have pets. Yet the number of overweight and obese in our furry family members also is a growing concern. Professor Je-Ruei Liu has been engaged in research on obesity related topics for many years, hoping to apply natural products to delay aging, to reduce pet weight, and to promote healthier diets for our pets.
 

Interview of Professor Li-Ying, Sung

Professor Sung is an expert in SCNT and among the first to report cloned mice using terminally differentiated postmitotic granulocytes, followed by efficient derivation of mouse ntESCs. Her team also cloned cattle and rabbits before.  She excels in embryonic technologies, such as SCNT, pronuclear microinjection, intracytoplasmic sperm injection, blastocyst injection, oocyte and embryo cryopreservation, as well as iPSC technology. Her research interests are embryology, developmental biology, stem cell biology, as well as development of novel animal models to study human diseases including infertility. She is also applying these modern tools to save endangered animals.

Interview of Professor Kuan-Chen Cheng

Being a professor in both Institute of Biotechnology (IOB) and Institute of Food Sciences and
Technology (FST) at National Taiwan University, Prof Cheng proofs his doubtlessly research
experiences in the areas of microbial bioprocessing, fermentation and biotechnology. His
laboratory currently focusing on four major topics which are bioactivity of medical mushroom,
Wine making and brewing, Development of Senior’s Food, and Biotechnology.

Interview of Professor Shih-Shun Lin

Birds migrate south for winter. Fishes swim to their ideal water current. Unlike animals, plants are not able to move freely forces the plants to adapt to the environment. It is a pleasure to invite Prof. Shih-Shun Lin from the Laboratory of Plant Molecular Biology and Virology to talk about gene regulation mechanisms that help the plants to survive from environmental adversity and disease invasion.
 
 

Interview of New Assistant Professor Shu-Han, Yu

  • 2020-08-14
  • Shu-Han Yu
The author:  Tjita Veny (徐溶佩) & Ru-Ting Yang (楊如婷)

Today we interviewed our new faculty, Dr. Shu-Han Yu, who has immuno-oncology, immune modulation, tumor microenvironment, and microbiome professional with 9+ years of academic research experience and 4+ years of industrial experience. She has committed to transforming expertise in translational medicine into non-small-cell lung cancer precision medicine, microbiome profiling, biomarker discovery, characterization, clinical validation, and potential diagnostics.

Among various fields in scientific research, what exactly did immuno-oncology have to attract Dr. Yu to work on this field? She explained that being exposed to biology and microbiology during her four years of university life made her gradually interested in molecular biology. After joined the laboratory, she was exposed to proteomics and cancer-related research, and finally went all the way to Johns Hopkins University, where she witnessed the development of cancer therapeutic drugs, such as AMP-514, an anti-programmed cell death 1 (PD-1) antibody drug, and began to show interest in immuno-oncology. In the development of immuno-oncology, from the 1970s, the key factor of bacteria contribution in cancer control-tumor necrosis factor-α (TNF-α) was identified. In the 1980s, IL-2 cultured T cells were used in cancer treatment. In the 1990s, immune checkpoint molecules were used in cancer treatment because of the discovery of PD-1 and CTLA-4. And all of those were created in just few decades. With the development of science and technology, various new technologies have come out one after another, and this field has also made rapid progress, so that cancer patients have more suitable treatment options. This is also the reason why Dr. Yu has devoted herself to this field.

Now that there has been such a vigorous development in tumor immunity, what will be the next stage? What else can immunotherapy bring us? The tumor immune microenvironment (TIME) is composed of neoplastic cells and their surrounding non-neoplastic stroma, along with a wide variety of immune cells. TIME can be described according to the abundance and type of immune infiltrates, the localization of immune infiltrates, and the functional structures of immune infiltrates. Therefore, it is critical to uncover the immune components and the need to establish a set of "standardized analysis" has become an important part of refined medicine, carrying out personalized medicine based on the analysis results. Dr. Yu’s laboratory has a well-defined focus on the immune mechanisms in the tumor microenvironment, adoptive cell therapy, and the potential role of the microbiome in cancer initiation and progression. 

In addition, lung cancer is the leading cause of cancer death worldwide. Due to the living habits as well as early detection difficulties, lung cancer has become the first leading cause of cancer death. Current treatment plans include chemotherapy, radiation therapy, surgery, and targeted therapy. In recent years, immunotherapy including antibody-mediated tumor regression, checkpoint blockade, and adoptive cell therapy (ACT) acts as potential strategies to cure cancer. With the young scholar fellowship, Dr. Yu’s lab aims to establish high-yield neoantigen specific T cell banks for lung cancer immunotherapy. 


(Steven A. Rosenberg et al, 2015)


Finally, speaking from her experience, Dr. Yu suggested who are studying in the field of biology should start to think about the future directions, whether to continue the study or to go to the industry. For those who want to stay in academia must be really clear about the field of interest, not just for the sake of a diploma. For those who decide to work in the industry must start to develop required skills in advance to increase the chance and possibility to stay in the field longer.